Journal article
A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division
- Abstract:
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Leishmaniasis is a neglected disease that affects more than 12 million people, with a limited therapy. Plant-derived natural products represent a useful source of anti-protozoan prototypes. In this work, four derivatives were prepared from neolignans isolated from the Brazilian plant Nectandra leucantha, and their effects against intracellular amastigotes of Leishmania (L.) infantum evaluated in vitro. IC50 values between 6 and 35 µM were observed and in silico predictions suggested good oral...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 9
- Issue:
- 1
- Article number:
- 6114
- Publication date:
- 2019-04-16
- Acceptance date:
- 2019-03-26
- DOI:
- EISSN:
-
2045-2322
- Pmid:
-
30992481
Item Description
- Keywords:
- Pubs id:
-
pubs:995248
- UUID:
-
uuid:c96e7ee0-0278-4cc7-8481-8d7f000579af
- Local pid:
- pubs:995248
- Source identifiers:
-
995248
- Deposit date:
- 2019-05-17
Terms of use
- Copyright holder:
- Amaral, M et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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