DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

Journal article

TNF-alpha and lymphotoxin (LT, TNF-beta) genes are tandemly arranged and map within the MHC centromeric to HLA-B and telomeric to the class III genes. Both cytokines encoded by these genes are potent immunomodulators. On the other hand, some MHC-linked autoimmune diseases are characterized by abnormal levels of their expression or inducibility. A search for the putative disease-associated TNF/LT alleles depends on the informative genetic markers at the TNF locus. Previously, a low degree of g...

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Authors: Nedospasov, SA; Udalova, I; Kuprash, D; Turetskaya, R

• Journal: Journal of Immunology
• Volume: 147
• Issue: 3
• Pages: 1053-1059
• Publication date: 1991-08-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Alleles; Polymerase Chain Reaction; Blotting, Southern; DNA, Satellite; Tumor Necrosis Factor-alpha; Polymorphism, Genetic; Humans; Base Sequence; Chromosome Mapping; Pedigree; Molecular Sequence Data; Oligonucleotide Probes; Lymphotoxin-alpha