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DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

Abstract:

TNF-alpha and lymphotoxin (LT, TNF-beta) genes are tandemly arranged and map within the MHC centromeric to HLA-B and telomeric to the class III genes. Both cytokines encoded by these genes are potent immunomodulators. On the other hand, some MHC-linked autoimmune diseases are characterized by abnormal levels of their expression or inducibility. A search for the putative disease-associated TNF/LT alleles depends on the informative genetic markers at the TNF locus. Previously, a low degree of g...

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Journal:
Journal of Immunology More from this journal
Volume:
147
Issue:
3
Pages:
1053-1059
Publication date:
1991-08-01
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:374951
UUID:
uuid:c96d2747-ff5e-4a8e-9f3c-b92ffab8fd10
Local pid:
pubs:374951
Source identifiers:
374951
Deposit date:
2013-11-16

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