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Journal article

Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus.

Abstract:

BACKGROUND: Common variable immunodeficiency is the most common primary immunodeficiency. A subset of patients has debilitating inflammatory complications. OBJECTIVES: We investigated the role of cytomegalovirus (CMV), and the T-cell response targeted at this virus, in this inflammatory disease. METHODS: Phenotypic and functional assays were used to profile CMV-specific T cells in patients with common variable immunodeficiency with and without inflammatory complications. Highly sensitive imm...

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Publication status:
Published

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Publisher copy:
10.1016/j.jaci.2011.04.001

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Journal:
Journal of allergy and clinical immunology
Volume:
127
Issue:
6
Pages:
1385-93.e4
Publication date:
2011-06-01
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
Source identifiers:
138809
Language:
English
Keywords:
Pubs id:
pubs:138809
UUID:
uuid:c96cb581-c363-42c5-a478-a0ec4ae09436
Local pid:
pubs:138809
Deposit date:
2012-12-19

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