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Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.

Abstract:

Background

Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine tissue or cell identity and driving tumor progression. Although previous approaches have been tried to explain risk associated with SNPs in regulatory DNA elements, so far epigenetic readers such as bromodomain containing protein 4 (B...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12864-017-3620-y

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
Linacre College
Role:
Author
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Contributors

Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Cancer Epidemiology Unit
Oxford college:
Wolfson College
Role:
Contributor
Department of Health More from this funder
Canadian Institute for Health Research More from this funder
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Genomics Journal website
Volume:
18
Issue:
1
Pages:
270
Publication date:
2017-03-05
Acceptance date:
2017-03-11
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
Pubs id:
pubs:689058
URN:
uri:c962f18f-77c7-48ea-886c-3782a5dba900
UUID:
uuid:c962f18f-77c7-48ea-886c-3782a5dba900
Local pid:
pubs:689058

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