Journal article
Getting out of mitosis: Spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A
- Abstract:
-
Here, we will review the evidence showing that mitotic exit is initiated by regulated proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases. Rapid APC/CCDC 20 and ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chromatid separation, the first step of mitotic exit. Because proteolysis of Aurora and Polo family kinases dependent on APC/CCDH 1 is relatively slow, this creates a new regulatory state, anaphase, different to G2 and M-phase. W...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- FEBS Letters
- Volume:
- 593
- Issue:
- 20
- Pages:
- 2908-2924
- Publication date:
- 2019-09-18
- Acceptance date:
- 2019-08-19
- DOI:
- EISSN:
-
1873-3468
- ISSN:
-
0014-5793
- Pmid:
-
31494926
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1054216
- UUID:
-
uuid:c961281b-0e49-4930-af1d-8b9177e394e1
- Local pid:
- pubs:1054216
- Source identifiers:
-
1054216
- Deposit date:
- 2020-01-06
Terms of use
- Copyright holder:
- Federation of European Biochemical Societies
- Copyright date:
- 2019
- Rights statement:
- © 2019 Federation of European Biochemical Societies.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/1873-3468.13595
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