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Solution- and solid-state NMR studies of GPCRs and their ligands.

Abstract:

G protein-coupled receptors (GPCRs) represent one of the major targets of new drugs on the market given their roles as key membrane receptors in many cellular signalling pathways. Structure-based drug design has potential to be the most reliable method for novel drug discovery. Unfortunately, GPCR-ligand crystallisation for X-ray diffraction studies is very difficult to achieve. However, solution- and solid-state NMR approaches have been developed and have provided new insights, particularly ...

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Publication status:
Published

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Authors


Tapaneeyakorn, S More by this author
Goddard, AD More by this author
Willis, CL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Biochimica et biophysica acta
Volume:
1808
Issue:
6
Pages:
1462-1475
Publication date:
2011-06-05
DOI:
ISSN:
0006-3002
URN:
uuid:c95c46e0-d6ca-455f-b75c-e76d29677bd6
Source identifiers:
99961
Local pid:
pubs:99961

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