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Direct ex-vivo evaluation of pneumococcal specific T-cells in healthy adults.

Abstract:

Streptococcus pneumoniae is an encapsulated bacterium that causes significant global morbidity and mortality. The nasopharynxes of children are believed to be the natural reservoir of pneumococcus and by adulthood nasopharyngeal carriage is infrequent; such infrequency may be due to demonstrable pneumococcal specific T and B-cell responses. HLA Class 2 tetrameric complexes have been used to characterise antigen specific T-cell responses in a variety of models of infection. We therefore sought...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0025367

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
PloS one
Volume:
6
Issue:
10
Pages:
e25367
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:c94ce199-92af-47fa-a759-0f748fb67363
Source identifiers:
198755
Local pid:
pubs:198755

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