Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes.

Journal article

INTRODUCTION: Systemic lupus erythematosus (SLE) and rheumatoid arthritis have complex genetic traits, but in both autoimmune diseases, dysfunctional apoptosis appears to play a part in disease pathology. This study examined the levels of in vitro apoptosis in lymphocytes from healthy, rheumatoid arthritis (RA) and SLE individuals and related observed differences to their lymphocyte apoptosis gene profiles. MATERIALS AND METHODS: Lymphocytes were assessed for cell death by nuclear pyknosis a...

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Authors: Eggleton, P; Harries, L; Alberigo, G; Wordsworth, P; Viner, N

• Publication status: Published
• Journal: Journal of clinical immunology
• Volume: 30
• Issue: 5
• Pages: 649-658
• Publication date: 2010-09-01
• DOI: 10.1007/s10875-010-9429-y
• EISSN: 1573-2592
• ISSN: 0271-9142
• Language: English
• Keywords: Gene Expression Profiling; Gene Expression Regulation; Female; Cells, Cultured; Adult; Middle Aged; Death Domain Receptor Signaling Adaptor Proteins; Lymphocytes; Male; CARD Signaling Adaptor Proteins; Arthritis, Rheumatoid; Aged; Humans; Apoptosis; Lupus Erythematosus, Systemic