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NAADP receptors

Abstract:

Of the established Ca2+-mobilizing messengers, NAADP is arguably the most tantalizing. It is the most potent, often efficacious at low nanomolar concentrations, and its receptors undergo dramatic desensitization. Recent studies have identified a new class of calcium-release channel, the two-pore channels (TPCs), as the likely targets for NAADP regulation, even though the effect may be indirect. These channels localized at endolysosomes, where they mediate local Ca2+ release, and have highligh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/cshperspect.a035071

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
New College
Role:
Author
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Cold Spring Harbor Perspectives in Biology Journal website
Volume:
11
Issue:
11
Article number:
a035071
Publication date:
2019-06-10
Acceptance date:
2019-04-02
DOI:
EISSN:
1943-0264
Pmid:
31182546
Source identifiers:
1013660
Language:
English
Keywords:
Pubs id:
pubs:1013660
UUID:
uuid:c948d652-8cf9-429c-a11e-775e3f0997b3
Local pid:
pubs:1013660
Deposit date:
2019-06-27

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