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Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Abstract:

AIMS/HYPOTHESIS: Insulin signalling pathways regulate pancreatic beta cell function. Conditional gene targeting using the Cre/loxP system has demonstrated that mice lacking insulin receptor substrate 2 (IRS2) in the beta cell have reduced beta cell mass. However, these studies have been complicated by hypothalamic deletion when the RIPCre (B6.Cg-tg(Ins2-cre)25Mgn/J) transgenic mouse (expressing Cre recombinase under the control of the rat insulin II promoter) is used to delete floxed alleles ...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-007-0637-9

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Choudhury, AI More by this author
Asare-Anane, H More by this author
Lingard, S More by this author
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Journal:
Diabetologia
Volume:
50
Issue:
6
Pages:
1248-1256
Publication date:
2007-06-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:c9476004-22fd-4a41-b63d-351388f4b6f8
Source identifiers:
386918
Local pid:
pubs:386918

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