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Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

Abstract:

OBJECTIVE: The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well-recognized. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterize adipokine and inflammatory cytokine profiles in IIH. DESIGN: Paired serum and cerebrospinal fluid (CSF) specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples we...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Role:
Author
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Journal:
Clinical endocrinology
Volume:
70
Issue:
6
Pages:
863-869
Publication date:
2009-06-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:c94723f4-3fe4-49f6-9e1e-d69f183b4bfe
Source identifiers:
482087
Local pid:
pubs:482087

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