Structural and genetic characterisation of variant glycoforms of Haemophilus influenzae lipopolysaccharide; implications for virulence

Journal article

Haemophilus influenzae (Hi) type b transformants RM135 and RM133 were previously found to differ in virulence and capsule content [Zwahlen et a!., Microb Pathog 1986; 1: 465-73]. The more virulent strain RM135 produced less capsule than RM133, but was indicated to differ in its lipopolysaccharide (LPS). We have now performed detailed analyses of the respective LPSs and correlate structure, genetics and the original virulence observation. We found that RM133 expressed identical major LPS struc...

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Authors: Schweda, E; Hood, D; Månsson, M; Martin, A; Richards, J

• Journal: Research Journal of Microbiology
• Volume: 5
• Issue: 10
• Pages: 986-998
• Publication date: 2010-01-01
• DOI: 10.3923/jm.2006.294.306
• ISSN: 1816-4935
• Language: English
• Keywords: Digalactosice; Lipopolysaccharide; Lic2A; Haemophilus influenzae; Sialic acid; Virulence