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Lysine methylation regulates the pRb tumour suppressor protein.

Abstract:

The pRb tumour suppressor protein has a central role in coordinating early cell cycle progression. An important level of control imposed on pRb occurs through post-translational modification, for example, phosphorylation. We describe here a new level of regulation on pRb, mediated through the targeted methylation of lysine residues, by the methyltransferase Set7/9. Set7/9 methylates the C-terminal region of pRb, both in vitro and in cells, and methylated pRb interacts with heterochromatin pro...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2009.511
Journal:
Oncogene More from this journal
Volume:
29
Issue:
16
Pages:
2357-2367
Publication date:
2010-04-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Language:
English
Keywords:
Pubs id:
pubs:248164
UUID:
uuid:c93ff1e6-1764-4ea5-b894-8975a317c6dd
Local pid:
pubs:248164
Source identifiers:
248164
Deposit date:
2012-12-19

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