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Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability.

Abstract:

Defects in the DNA mismatch repair proteins result in microsatellite instability and malignancy in hereditary non-polyposis colorectal carcinoma (HNPCC). However, the role of mismatch repair (MMR) proteins and microsatellite instability (MSI) in transitional cell carcinoma of the bladder is less clear. In our study, the expression of 2 MMR proteins and the frequency of MSI in Transitional cell carcinoma of the bladder (TCC) were investigated. One hundred eleven patients with TCC of the bladde...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.11109

Authors


Xinarianos, G More by this author
Burton, JL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Journal:
International journal of cancer. Journal international du cancer
Volume:
105
Issue:
4
Pages:
484-490
Publication date:
2003-07-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:c93f2436-9bb9-4a9c-830e-bfba966771ad
Source identifiers:
120648
Local pid:
pubs:120648

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