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Sonic Hedgehog regulates thymic epithelial cell differentiation

Abstract:

Sonic Hedgehog (Shh) is expressed in the thymus, where it regulates T cell development. Here we investigated the influence of Shh on thymic epithelial cell (TEC) development. Components of the Hedgehog (Hh) signalling pathway were expressed by TEC, and use of a Gli Binding Site-green fluorescence protein (GFP) transgenic reporter mouse demonstrated active Hh-dependent transcription in TEC in the foetal and adult thymus. Analysis of Shh-deficient foetal thymus organ cultures (FTOC) showed that...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jaut.2015.12.004

Authors


Saldana, JI More by this author
Solanki, A More by this author
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Medical Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Publication date:
2016
DOI:
ISSN:
1095-9157
URN:
uuid:c93c4630-a368-4511-b488-6d677b06f276
Source identifiers:
581080
Local pid:
pubs:581080

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