Journal article
Cobalt versus osmium: control of both trans and cis selectivity in construction of the EFG rings of pectenotoxin 4
- Abstract:
- Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt or osmium based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
AstraZeneca
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GlaxoSmithKline
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Volume:
- 56
- Issue:
- 47
- Pages:
- 14883–14887
- Publication date:
- 2017-10-19
- Acceptance date:
- 2017-09-19
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- Pmid:
-
28926175
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:730156
- UUID:
-
uuid:c9398b4b-2b23-46ed-8271-9300a6fc0246
- Local pid:
- pubs:730156
- Source identifiers:
-
730156
- Deposit date:
- 2017-09-22
Terms of use
- Copyright holder:
- Wiley-VCH Verlag GmbH & Co KGaA, Weinheim
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted manuscript version of the article. The final version is available online from Wiley-VCH Verlag at: https://doi.org/10.1002/anie.201708278
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