Journal article icon

Journal article

Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

Abstract:

The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). In this article, we report the functional characterization of an mAb that recognizes a panel of PfEMP1s and inhibits ICAM-1 binding. The 24E9 mouse mAb was raised against PFD1235w DBLβ3_D4, a domain from the group A PfEMP1s associated with severe malaria. 24E9 recognizes native PfEMP1 expressed o...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Medical Research Council
Funding agency for:
Lennartz, F
Publisher:
American Association of Immunologists
Journal:
Journal of Immunology More from this journal
Volume:
195
Issue:
7
Pages:
3273-3283
Publication date:
2015-10-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Pubs id:
pubs:541807
UUID:
uuid:c938e818-095b-4784-bb6d-006d2f1df49b
Local pid:
pubs:541807
Source identifiers:
541807
Deposit date:
2015-10-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP