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Chemical mutagenesis: selective post-expression interconversion of protein amino acid residues.

Abstract:

The ability to alter protein structure by site-directed mutagenesis has revolutionized biochemical research. Controlled mutations at the DNA level, before protein translation, are now routine. These techniques allow specific, high fidelity interconversion largely between 20 natural, proteinogenic amino acids. Nonetheless, there is a need to incorporate other amino acids, both natural and unnatural, that are not accessible using standard site-directed mutagenesis and expression systems. Post-t...

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Publication status:
Published

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Publisher copy:
10.1016/j.cbpa.2010.10.007

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Current opinion in chemical biology
Volume:
14
Issue:
6
Pages:
781-789
Publication date:
2010-12-01
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
Source identifiers:
97249
Language:
English
Keywords:
Pubs id:
pubs:97249
UUID:
uuid:c9367bdb-c4fa-470a-9db4-4d5e2bf1e988
Local pid:
pubs:97249
Deposit date:
2012-12-19

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