- Abstract:
-
INTRODUCTION: The ionic basis underlying the negative chronotropic effect of acetylcholine (ACh) on sinoatrial (SA) node cells is unresolved and controversial. In the present study, mathematical modeling was used to address this issue. METHODS AND RESULTS: The known concentration-dependent effects of ACh on iK,ACh, iCa,L, and i(f) were introduced into models of rabbit central and peripheral SA node cells. In the central and peripheral models, 9 x 10(-8) and 14 x 10(-8) M ACh, respectively, c...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1046/j.1540-8167.2002.00465.x
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- Journal:
- Journal of cardiovascular electrophysiology
- Volume:
- 13
- Issue:
- 5
- Pages:
- 465-474
- Publication date:
- 2002-05-05
- DOI:
- EISSN:
-
1540-8167
- ISSN:
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1045-3873
- URN:
-
uuid:c93477cf-c05a-4c7d-94c8-f839ecd6469e
- Source identifiers:
-
346027
- Local pid:
- pubs:346027
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells.
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