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Journal article

Analysis of the chronotropic effect of acetylcholine on sinoatrial node cells.

Abstract:

INTRODUCTION: The ionic basis underlying the negative chronotropic effect of acetylcholine (ACh) on sinoatrial (SA) node cells is unresolved and controversial. In the present study, mathematical modeling was used to address this issue. METHODS AND RESULTS: The known concentration-dependent effects of ACh on iK,ACh, iCa,L, and i(f) were introduced into models of rabbit central and peripheral SA node cells. In the central and peripheral models, 9 x 10(-8) and 14 x 10(-8) M ACh, respectively, c...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Journal of cardiovascular electrophysiology
Volume:
13
Issue:
5
Pages:
465-474
Publication date:
2002-05-05
DOI:
EISSN:
1540-8167
ISSN:
1045-3873
URN:
uuid:c93477cf-c05a-4c7d-94c8-f839ecd6469e
Source identifiers:
346027
Local pid:
pubs:346027

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