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Allowing for non-adherence to treatment in a randomized controlled trial of two antidepressants (citalopram versus reboxetine): an example from the GENPOD trial.

Abstract:

BACKGROUND: Meta-analyses suggest that reboxetine may be less effective than other antidepressants. Such comparisons may be biased by lower adherence to reboxetine and subsequent handling of missing outcome data. This study illustrates how to adjust for differential non-adherence and hence derive an unbiased estimate of the efficacy of reboxetine compared with citalopram in primary care patients with depression. METHOD: A structural mean modelling (SMM) approach was used to generate adherence...

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Publication status:
Published

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Publisher copy:
10.1017/s0033291714000221

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Psychological medicine
Volume:
44
Issue:
13
Pages:
2855-2866
Publication date:
2014-10-05
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
URN:
uuid:c932f18c-3d59-4a14-9880-8c1fefdec004
Source identifiers:
478356
Local pid:
pubs:478356

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