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Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase.

Abstract:

Recoverin is a calcium-dependent inhibitor of rhodopsin kinase. It prevents premature phosphorylation of rhodopsin until the opening of cGMP-gated ion channels causes a decrease in intracellular calcium levels, signaling completion of the light response. This calcium depletion causes release of recoverin from rhodopsin kinase, freeing the kinase to phosphorylate rhodopsin and to terminate the light response. Previous studies have shown that recoverin is able to bind to a region at the N termi...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.M602203200

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
281
Issue:
28
Pages:
19426-19432
Publication date:
2006-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:c9325cc1-ca96-4cee-b152-7f213846d301
Source identifiers:
196856
Local pid:
pubs:196856

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