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High Mobility Group Box 1 and Interleukin 6 at intensive care unit admission as biomarkers in critically ill COVID-19 patients

Abstract:

Exuberant inflammation manifesting as a “cytokine storm” has been suggested as a central feature in the pathogenesis of severe coronavirus disease 2019 (COVID-19). This study investigated two prognostic biomarkers, the high mobility group box 1 (HMGB1) and interleukin-6 (IL-6), in patients with severe COVID-19 at the time of admission in the intensive care unit (ICU). Of 60 ICU patients with COVID-19 enrolled and analyzed in this prospective cohort study, 48 patients (80%) were alive at ICU d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Publisher:
American Society of Tropical Medicine and Hygiene
Journal:
American Journal of Tropical Medicine and Hygiene More from this journal
Volume:
105
Issue:
1
Pages:
73-80
Publication date:
2021-05-03
Acceptance date:
2021-04-19
DOI:
EISSN:
1476-1645
Language:
English
Keywords:
Pubs id:
1181085
Local pid:
pubs:1181085
Deposit date:
2021-06-08

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