Insights into function of the immunological synapse from studies with supported planar bilayers.

Journal article

Innate and adaptive immunity is dependent upon reliable cell-cell communication mediated by direct interactions of cell surface receptors with ligands integrated into the surface of apposing cells or bound directly to the surface as in complement deposition or antibody mediated recognition through Fc receptors. Supported lipid bilayers formed on glass surfaces offer a useful model system in which to explore some basic features of molecular interactions in immunological relevant contacts, whic...

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Authors: Dustin, M

• Journal: Current topics in microbiology and immunology
• Volume: 340
• Pages: 1-24
• Publication date: 2010-01-01
• DOI: 10.1007/978-3-642-03858-7_1
• ISSN: 0070-217X
• Language: English
• Keywords: Lipid Bilayers; Cell Division; Humans; Immunological Synapses; Lymphocyte Activation; Signal Transduction; Receptors, Antigen, T-Cell; Animals; Actins