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Characterization of monoclonal antibodies against rabbit CD44: evidence of a role for CD44 in modulating synoviocyte metabolism.

Abstract:

The CD44 adhesion receptor is a hyaluronan-binding cell surface glycoprotein whose major isoform is a 95 kDa molecule with a wide tissue distribution. We have characterized two MAbs, W4/86 and RPN3/24, by immunochemistry, flow cytometry and fluorescence staining and demonstrated that they recognize the rabbit CD44 molecule. The results show that CD44 in the rabbit has a similar molecular size and cell distribution to human CD44. These antibodies have demonstrated for the first time, the prese...

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Publication status:
Published

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Authors


Galea-Lauri, J More by this author
Wilkinson, JM More by this author
Journal:
Molecular immunology
Volume:
30
Issue:
15
Pages:
1383-1392
Publication date:
1993-10-05
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
URN:
uuid:c92aa7b0-8200-46ab-9e80-0d3b60fa6d1b
Source identifiers:
466406
Local pid:
pubs:466406

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