Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.

Journal article

To gain insight into the poorly understood pathophysiology of the myelodysplastic syndromes (MDSs), we have determined the gene expression profiles of the CD34+ cells of 55 patients with MDS by using a comprehensive array platform. These profiles showed many similarities to reported interferon-gamma-induced gene expression in normal CD34+ cells; indeed the 2 most up-regulated genes, IFIT1 and IFITM1, are interferon-stimulated genes (ISGs). Alterations in the expression of ISGs may play a role...

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Authors: Pellagatti, A; Cazzola, M; Giagounidis, A; Malcovati, L; Porta, MG

• Publication status: Published
• Journal: Blood
• Volume: 108
• Issue: 1
• Pages: 337-345
• Publication date: 2006-07-01
• DOI: 10.1182/blood-2005-12-4769
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: International Cooperation; Bone Marrow Cells; Adaptor Proteins, Signal Transducing; Reverse Transcriptase Polymerase Chain Reaction; Interferons; Humans; Myelodysplastic Syndromes; Phylogeny; Karyotyping; Antigens, CD34; Gene Expression Profiling