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The role of Sp1 and NF-kappa B in regulating CD40 gene expression.

Abstract:

CD40 is a member of the tumor necrosis factor receptor superfamily and is a key signaling molecule expressed by antigen-presenting cells of the immune system. In a previous paper, we demonstrated that the expression of CD40 is regulated by both post-transcriptional and post-translational processes. In this paper, we show that basal (constitutive) CD40 gene expression is regulated by a TATA-less promoter, with Sp1 as a key transcription factor. Two Sp1 binding regions were identified in the mo...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109889200

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of biological chemistry
Volume:
277
Issue:
11
Pages:
8890-8897
Publication date:
2002-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:c91b4a47-785c-481c-b1d0-eb29f62898de
Source identifiers:
16423
Local pid:
pubs:16423

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