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Stereotypic wheel running decreases cortical activity in mice

Abstract:

Prolonged wakefulness is thought to gradually increase 'sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms13138

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Experimental Psychology
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Author
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Grant:
FP7-PEOPLE-CIG (PCIG11-GA-2012-322050)
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Grant:
Research Fund Grant (131/032)
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Grant:
Strategic Award (098461/Z/12/Z)
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
Article: 13138
Publication date:
2016-10-17
DOI:
ISSN:
2041-1723
Pubs id:
pubs:653426
URN:
uri:c91421f5-a6bb-4b30-9e14-5dd72398ab03
UUID:
uuid:c91421f5-a6bb-4b30-9e14-5dd72398ab03
Local pid:
pubs:653426
Language:
English
Keywords:

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