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Journal article

Stereotypic wheel running decreases cortical activity in mice

Abstract:

Prolonged wakefulness is thought to gradually increase 'sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms13138

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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Grant:
FP7-PEOPLE-CIG (PCIG11-GA-2012-322050
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Grant:
Research Fund Grant (131/032
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Grant:
Strategic Award (098461/Z/12/Z
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Article number:
13138
Publication date:
2016-10-17
DOI:
ISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
pubs:653426
UUID:
uuid:c91421f5-a6bb-4b30-9e14-5dd72398ab03
Local pid:
pubs:653426
Deposit date:
2016-11-09

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