Journal article
Derisking the Cu-mediated (18)F-fluorination of heterocyclic positron emission tomography radioligands
- Abstract:
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Molecules labeled with fluorine-18 ((18)F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of (18)F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioli...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.8MB)
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- Publisher copy:
- 10.1021/jacs.7b03131
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Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Grant:
EP/L025604/1, NS/A000024/1
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of the American Chemical Society Journal website
- Volume:
- 139
- Issue:
- 24
- Pages:
- 8267-8276
- Publication date:
- 2017-06-21
- DOI:
- EISSN:
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1520-5126
- ISSN:
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0002-7863
- Source identifiers:
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698095
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:698095
- UUID:
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uuid:c9081f5a-28df-410f-b657-b20a9ee92d96
- Local pid:
- pubs:698095
- Deposit date:
- 2017-07-31
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/jacs.7b03131
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