- Abstract:
-
Molecules labeled with fluorine-18 ((18)F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of (18)F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioli...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.8mb)
-
- Publisher copy:
- 10.1021/jacs.7b03131
-
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- Grant:
- EP/L025604/1, NS/A000024/1
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of the American Chemical Society Journal website
- Volume:
- 139
- Issue:
- 24
- Pages:
- 8267-8276
- Publication date:
- 2017-06-21
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- Pubs id:
-
pubs:698095
- URN:
-
uri:c9081f5a-28df-410f-b657-b20a9ee92d96
- UUID:
-
uuid:c9081f5a-28df-410f-b657-b20a9ee92d96
- Local pid:
- pubs:698095
- Language:
- English
- Keywords:
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/jacs.7b03131
Journal article
Derisking the Cu-mediated (18)F-fluorination of heterocyclic positron emission tomography radioligands
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