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Derisking the Cu-mediated (18)F-fluorination of heterocyclic positron emission tomography radioligands

Abstract:

Molecules labeled with fluorine-18 ((18)F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of (18)F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioli...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/jacs.7b03131

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Preshlock, S More by this author
Schedler, M More by this author
Tredwell, M More by this author
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
139
Issue:
24
Pages:
8267-8276
Publication date:
2017-06-21
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:698095
URN:
uri:c9081f5a-28df-410f-b657-b20a9ee92d96
UUID:
uuid:c9081f5a-28df-410f-b657-b20a9ee92d96
Local pid:
pubs:698095
Language:
English
Keywords:

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