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Journal article

Adaptin evolution in kinetoplastids and emergence of the variant surface glycoprotein coat in African trypanosomatids.

Abstract:

The kinetoplastids are an important group of protozoa from the Excavata supergroup, and cause numerous diseases with wide environmental, economic and ecological impact. Trypanosoma brucei, the causative agent of human African trypanosomiasis, expresses a dense variant surface glycoprotein (VSG) coat, facilitating immune evasion via rapid switching and antigenic variation. Coupled to VSG switching is efficient clathrin-mediated endocytosis (CME), which removes anti-VSG antibody from the parasi...

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Publication status:
Published

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Publisher copy:
10.1016/j.ympev.2013.01.002

Authors


Journal:
Molecular phylogenetics and evolution
Volume:
67
Issue:
1
Pages:
123-128
Publication date:
2013-04-05
DOI:
EISSN:
1095-9513
ISSN:
1055-7903
URN:
uuid:c906c9c9-0527-4cef-b1db-c68590897d3e
Source identifiers:
384746
Local pid:
pubs:384746

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