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Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

Abstract:

Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1616502114

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
093305/Z/10/Z
More from this funder
Name:
Medical Research Council
Grant:
MR/N00065X/1
More from this funder
Name:
National Science Foundation
Grant:
81520108019
More from this funder
Name:
Chinese Academy of Sciences
Grant:
XDB08020200
More from this funder
Name:
Chinese Ministry of Science and Technology
Grant:
2014CB542800
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
114
Issue:
4
Pages:
770-775
Publication date:
2017-01-01
Acceptance date:
2016-12-16
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:670706
UUID:
uuid:c8fd2fa4-02fb-4fa9-b5a2-8041f2ca8c44
Local pid:
pubs:670706
Source identifiers:
670706
Deposit date:
2017-02-16

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