Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale.
The Mouse Grimace Scale (MGS) was developed for assessing pain severity, but the general applicability to complex post-surgical pain has not been established. We sought to determine whether the MGS provides benefits over and above a standard welfare scoring system for identifying pain in mice following experimental myocardial infarction. Female C57BL/6 mice (n = 60), anaesthetized with isoflurane, were subjected to thoracotomy with ligation of a coronary artery or sham procedure. A single sub...Expand abstract
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