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Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale.

Abstract:

The Mouse Grimace Scale (MGS) was developed for assessing pain severity, but the general applicability to complex post-surgical pain has not been established. We sought to determine whether the MGS provides benefits over and above a standard welfare scoring system for identifying pain in mice following experimental myocardial infarction. Female C57BL/6 mice (n = 60), anaesthetized with isoflurane, were subjected to thoracotomy with ligation of a coronary artery or sham procedure. A single sub...

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Authors


Faller, KM More by this author
McAndrew, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Experimental physiology
Publication date:
2014-12-05
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
URN:
uuid:c8f7744f-cbd1-4a45-a255-9660115ca363
Source identifiers:
493486
Local pid:
pubs:493486
Language:
English

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