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Effects of intermittent lower limb ischaemia on coronary blood flow and coronary resistance in pigs.

Abstract:

AIM: Intermittent limb ischaemia prior to cardiac ischaemia is a cardioprotective stimulus. This study was to investigate whether this peripheral stimulus had any effects on basal coronary blood flow and resistance, and to explore its potential mechanisms by studying the effect of femoral nerve transection and Katp blockade by glibenclamide. METHODS: Remote ischaemic preconditioning (rIPC) was induced by four 5-min cycles of lower limb ischaemia. Coronary resistance was measured using standar...

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Publication status:
Published

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Authors


Shimizu, M More by this author
Konstantinov, IE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Cheung, MH More by this author
Redington, AN More by this author
Journal:
Acta physiologica (Oxford, England)
Volume:
190
Issue:
2
Pages:
103-109
Publication date:
2007-06-05
DOI:
EISSN:
1748-1716
ISSN:
1748-1708
URN:
uuid:c8f52e64-38b7-463f-b94b-26d571ca5477
Source identifiers:
105198
Local pid:
pubs:105198

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