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The frequency and mechanism of loss of heterozygosity on chromosome 11q in breast cancer.

Abstract:

Loss of heterozygosity (LOH, allele loss) occurs frequently on the long arm of chromosome 11 in breast cancer. Seventy-one paired tumour/normal DNA samples from breast cancer patients under 50 years old were studied for allele loss at four microsatellite loci on 11q: D11S29 (11q23.3), NCAM (11q22-q23), D11S968 (11qtel), and D11S1313 (11qcen). The maximum frequency of LOH (approximately 35 per cent) was found at the D11S29 and NCAM loci. This result is consistent with previous studies and the ...

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Authors


Tomlinson, IP More by this author
Nicolai, H More by this author
Solomon, E More by this author
Bodmer, WF More by this author
Journal:
The Journal of pathology
Volume:
180
Issue:
1
Pages:
38-43
Publication date:
1996-09-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:c8f488fd-cf8f-4e19-baab-7ed8e8b0cd6e
Source identifiers:
72312
Local pid:
pubs:72312

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