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Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells.

Abstract:

Astrocytes are nonprofessional APCs that may participate in Ag presentation and activation of pathogenic CD4+ T cells involved in central nervous system (CNS) inflammatory diseases. Using immortalized pure astrocytes as a complement to the study of primary astrocytes, we investigated whether these astrocytes express elements involved in the class II endocytic pathway and if they are capable of processing native myelin basic protein (MBP), a step that could be necessary for initiating or perpe...

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Publication status:
Published

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Authors


Ashley, TA More by this author
Szente, BE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
161
Issue:
11
Pages:
5959-5966
Publication date:
1998-12-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:c8f3b3b6-8131-4656-89da-d4873be62ac3
Source identifiers:
13853
Local pid:
pubs:13853

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