NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome.

Journal article

The influenza virus RNA polymerase transcribes the negative-sense viral RNA segments (vRNA) into mRNA and replicates them via complementary RNA (cRNA) intermediates into more copies of vRNA. It is not clear how the relative amounts of the three RNA products, mRNA, cRNA and vRNA, are regulated during the viral life cycle. We found that in viral ribonucleoprotein (vRNP) reconstitution assays involving only the minimal components required for viral transcription and replication (the RNA polymera...

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Authors: Robb, N; Smith, M; Vreede, F; Fodor, E

• Publication status: Published
• Journal: Journal of general virology
• Volume: 90
• Issue: Pt 6
• Pages: 1398-1407
• Publication date: 2009-06-01
• DOI: 10.1099/vir.0.009639-0
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Viral Proteins; Transcription, Genetic; Sequence Alignment; Influenza B virus; Humans; Protein Sorting Signals; Influenza A virus; Molecular Sequence Data; Virus Replication; Amino Acid Sequence; Sequence Deletion; Active Transport, Cell Nucleus