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Thesis

Eomesodermin governs the hemogenic competence of murine mesodermal progenitors

Abstract:

During mouse gastrulation pluripotent epiblast cells traverse the primitive streak (PS) and diversify into mesoderm and endoderm subtypes. The T-box transcription factor Eomesodermin (Eomes) is expressed during PS formation and is critical for the development of the cardiac mesoderm and definitive endoderm lineages. The earliest wave of progenitors to traverse the posterior PS give rise to extraembryonic mesoderm (ExM) that differentiates into the endothelium and hematopoietic progenitors ...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0003-3195-7246
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Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/501100000728
Grant:
10281/Z/13/Z
Programme:
Chromosome and Developmental Biology
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Name:
Trinity College, University of Oxford
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-01-03

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