Journal article
The structural basis for CD36 binding by the malaria parasite.
- Abstract:
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CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty acids. It is also the most common target of the PfEMP1 proteins of the malaria parasite, Plasmodium falciparum, tethering parasite-infected erythrocytes to endothelial receptors. This prevents their destruction by splenic clearance and allows increased parasitaemia. Here we describe the structure of CD36 in complex...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 2.4MB)
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.1038/ncomms12837
Authors
Funding
+ Taiwan Bio-Development Foundation
More from this funder
Funding agency for:
Hsieh, F
Grant:
Fellowship
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 7
- Publication date:
- 2016-09-26
- Acceptance date:
- 2016-08-04
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Pmid:
-
27667267
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:648100
- UUID:
-
uuid:c8ea3b54-eec4-4294-93cb-68405c096cd7
- Local pid:
- pubs:648100
- Source identifiers:
-
648100
- Deposit date:
- 2017-03-16
Terms of use
- Copyright holder:
- Hseih et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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