Journal article
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.
- Abstract:
-
T cell activation, a critical event in adaptive immune responses, depends on productive interactions between T cell receptors (TCRs) and antigens presented as peptide-bound major histocompatibility complexes (pMHCs). Activated T cells lyse infected cells, secrete cytokines, and perform other effector functions with various efficiencies, which depend on the binding parameters of the TCR-pMHC complex. The mechanism through which binding parameters are translated to the efficiency of T cell acti...
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- Publication status:
- Published
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- Publisher copy:
- 10.1126/scisignal.2001430
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Authors
Bibliographic Details
- Journal:
- Science signaling
- Volume:
- 4
- Issue:
- 176
- Pages:
- ra39
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1937-9145
- ISSN:
-
1937-9145
- Source identifiers:
-
151215
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:151215
- UUID:
-
uuid:c8e4202f-d494-4204-a4ac-af3fa0f8e214
- Local pid:
- pubs:151215
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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