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Journal article

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.

Abstract:

T cell activation, a critical event in adaptive immune responses, depends on productive interactions between T cell receptors (TCRs) and antigens presented as peptide-bound major histocompatibility complexes (pMHCs). Activated T cells lyse infected cells, secrete cytokines, and perform other effector functions with various efficiencies, which depend on the binding parameters of the TCR-pMHC complex. The mechanism through which binding parameters are translated to the efficiency of T cell acti...

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Publication status:
Published

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Publisher copy:
10.1126/scisignal.2001430

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Science signaling
Volume:
4
Issue:
176
Pages:
ra39
Publication date:
2011-01-01
DOI:
EISSN:
1937-9145
ISSN:
1937-9145
URN:
uuid:c8e4202f-d494-4204-a4ac-af3fa0f8e214
Source identifiers:
151215
Local pid:
pubs:151215

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