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Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus.

Abstract:

T-cell recognition of the antigenic peptides presented by MHC class I molecules normally triggers protective immune responses, but can result in immune enhancement of disease. Cross-reactive T-cell responses may underlie immunopathology in dengue haemorrhagic fever. To analyze these effects at the molecular level, the functional MHC class I molecule HLA-A*1101 was crystallized bound to six naturally occurring peptide variants from the dengue virus NS3 protein. The crystals contained high leve...

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Publication status:
Published

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Publisher copy:
10.1107/s1744309107013693

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Acta crystallographica. Section F, Structural biology and crystallization communications
Volume:
63
Issue:
Pt 5
Pages:
386-392
Publication date:
2007-05-05
DOI:
EISSN:
1744-3091
ISSN:
1744-3091
URN:
uuid:c8d21129-3d76-4808-a9d0-5f4260237a9b
Source identifiers:
24910
Local pid:
pubs:24910

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