Journal article
Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis
- Abstract:
-
As a protective envelope surrounding the bacterial cell, the peptidoglycan sacculus is a site of vulnerability and an antibiotic target. Peptidoglycan components, assembled in the cytoplasm, are shuttled across the membrane in a cycle that uses undecaprenyl-phosphate. A product of peptidoglycan synthesis, undecaprenyl-pyrophosphate, is converted to undecaprenyl-phosphate for reuse in the cycle by the membrane integral pyrophosphatase, BacA. To understand how BacA functions, we determine its c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Stansfeld, P
Grant:
BB/I019855/1, BB/P01948X/1, BB/R002517/1
+ Wellcome Trust
More from this funder
Funding agency for:
Stansfeld, P
Grant:
BB/I019855/1, BB/P01948X/1, BB/R002517/1
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 1
- Article number:
- 1078
- Publication date:
- 2018-03-14
- Acceptance date:
- 2018-02-14
- DOI:
- ISSN:
-
2041-1723
- Pmid:
-
29540682
- Source identifiers:
-
830327
Item Description
- Language:
- English
- Pubs id:
-
pubs:830327
- UUID:
-
uuid:c8c70b73-0a5d-4865-9a5e-186ee3c5434a
- Local pid:
- pubs:830327
- Deposit date:
- 2018-03-19
Terms of use
- Copyright holder:
- El Ghachi et al
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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