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Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis

Abstract:

As a protective envelope surrounding the bacterial cell, the peptidoglycan sacculus is a site of vulnerability and an antibiotic target. Peptidoglycan components, assembled in the cytoplasm, are shuttled across the membrane in a cycle that uses undecaprenyl-phosphate. A product of peptidoglycan synthesis, undecaprenyl-pyrophosphate, is converted to undecaprenyl-phosphate for reuse in the cycle by the membrane integral pyrophosphatase, BacA. To understand how BacA functions, we determine its c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-03477-5

Authors


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Funding agency for:
Stansfeld, P
Grant:
BB/I019855/1, BB/P01948X/1, BB/R002517/1
More from this funder
Funding agency for:
Stansfeld, P
Grant:
BB/I019855/1, BB/P01948X/1, BB/R002517/1
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Article number:
1078
Publication date:
2018-03-14
Acceptance date:
2018-02-14
DOI:
ISSN:
2041-1723
Pmid:
29540682
Source identifiers:
830327
Language:
English
Pubs id:
pubs:830327
UUID:
uuid:c8c70b73-0a5d-4865-9a5e-186ee3c5434a
Local pid:
pubs:830327
Deposit date:
2018-03-19

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