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The evolutionary dynamics of influenza A virus adaptation to mammalian hosts.

Abstract:

Few questions on infectious disease are more important than understanding how and why avian influenza A viruses successfully emerge in mammalian populations, yet little is known about the rate and nature of the virus' genetic adaptation in new hosts. Here, we measure, for the first time, the genomic rate of adaptive evolution of swine influenza viruses (SwIV) that originated in birds. By using a curated dataset of more than 24 000 human and swine influenza gene sequences, including 41 newly c...

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Publisher copy:
10.1098/rstb.2012.0382

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Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
368
Issue:
1614
Pages:
20120382-20120382
Publication date:
2013-03-19
DOI:
EISSN:
1471-2970
URN:
uuid:c8c1919f-baa1-47d8-9bde-aec5711418f3
Source identifiers:
416846
Local pid:
pubs:416846
Language:
English

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