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CD14- mononuclear stromal cells support (CD14+) monocyte-osteoclast differentiation in aneurysmal bone cyst.

Abstract:

Aneurysmal bone cyst (ABC) is a benign osteolytic bone lesion in which there are blood-filled spaces separated by fibrous septa containing giant cells. The nature of the giant cells in this lesion and the mechanism of bone destruction in ABC is not certain. In this study, we have analysed several characteristics of mononuclear and multinucleated cells in the ABC and examined the cellular and molecular mechanisms of ABC osteolysis. The antigenic and functional phenotype of giant cells in ABC w...

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Publication status:
Published

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Publisher copy:
10.1038/labinvest.2012.5

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Journal:
Laboratory investigation; a journal of technical methods and pathology
Volume:
92
Issue:
4
Pages:
600-605
Publication date:
2012-04-05
DOI:
EISSN:
1530-0307
ISSN:
0023-6837
URN:
uuid:c8ae507f-c5ae-4681-81b6-2ebb7c02311e
Source identifiers:
254309
Local pid:
pubs:254309

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