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Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism

Abstract:

The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function. Genetic variation involving VDR shows striking differences in allele frequency between populations and has been associated with disease susceptibility, including tuberculosis and autoimmunity, although results have often been conflicting. We hypothesized that methylation of VDR may be population specific an...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Human Immunology
Volume:
72
Issue:
3
Pages:
262-268
Publication date:
2011-03-01
DOI:
ISSN:
0198-8859
Source identifiers:
120517
Language:
English
Keywords:
Pubs id:
pubs:120517
UUID:
uuid:c8ac5e4e-7fbc-495e-b00c-66cea2b56784
Local pid:
pubs:120517
Deposit date:
2012-12-19

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