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Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism

Abstract:

The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function. Genetic variation involving VDR shows striking differences in allele frequency between populations and has been associated with disease susceptibility, including tuberculosis and autoimmunity, although results have often been conflicting. We hypothesized that methylation of VDR may be population specific an...

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Authors


Andraos, C More by this author
Koorsen, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Bornman, L More by this author
Journal:
Human Immunology
Volume:
72
Issue:
3
Pages:
262-268
Publication date:
2011-03-05
DOI:
ISSN:
0198-8859
URN:
uuid:c8ac5e4e-7fbc-495e-b00c-66cea2b56784
Source identifiers:
120517
Local pid:
pubs:120517

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