Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.

Journal article

CONTEXT: Low birth weight is associated with adverse metabolic outcome in adulthood. Exposure to glucocorticoid (GC) excess in utero is associated with decreased birth weight, but the prospective longitudinal relationship between GC metabolism and growth has not been examined. OBJECTIVE: We have hypothesized that changes in GC metabolism leading to increased availability may impair growth. DESIGN: This was a prospective, longitudinal study with clinical measurements and 24-hour urinary steroi...

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Authors: Rogers, S; Hughes, B; Jones, C; Freedman, L; Smart, K

• Publication status: Published
• Publisher: Endocrine Society
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 99
• Issue: 5
• Pages: E821-E831
• Publication date: 2014-05-01
• DOI: 10.1210/jc.2013-3254
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Humans; Weight Gain; Female; Prospective Studies; Male; Child Development; Infant; Infant, Newborn; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Body Weight; 11-beta-Hydroxysteroid Dehydrogenase Type 1