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Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.

Abstract:

CONTEXT: Low birth weight is associated with adverse metabolic outcome in adulthood. Exposure to glucocorticoid (GC) excess in utero is associated with decreased birth weight, but the prospective longitudinal relationship between GC metabolism and growth has not been examined. OBJECTIVE: We have hypothesized that changes in GC metabolism leading to increased availability may impair growth. DESIGN: This was a prospective, longitudinal study with clinical measurements and 24-hour urinary steroi...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2013-3254

Authors


Publisher:
Endocrine Society
Journal:
Journal of clinical endocrinology and metabolism More from this journal
Volume:
99
Issue:
5
Pages:
E821-E831
Publication date:
2014-05-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Language:
English
Keywords:
Pubs id:
pubs:482053
UUID:
uuid:c8a40bb7-a9ca-4fdc-b60b-057807828fa3
Local pid:
pubs:482053
Source identifiers:
482053
Deposit date:
2014-08-29

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