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Dynamical mechanism for subcellular alternans in cardiac myocytes.

Abstract:

RATIONALE: Cardiac repolarization alternans is an arrhythmogenic rhythm disturbance, manifested in individual myocytes as a beat-to-beat alternation of action potential durations and intracellular calcium transient magnitudes. Recent experimental studies have reported "subcellular alternans," in which distinct regions of an individual cell are seen to have counterphase calcium alternations, but the mechanism by which this occurs is not well understood. Although previous theoretical work has p...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Circulation research More from this journal
Volume:
105
Issue:
4
Pages:
335-342
Publication date:
2009-08-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:164560
UUID:
uuid:c8a3429e-696c-456b-a25b-c5c1dbb1deed
Local pid:
pubs:164560
Source identifiers:
164560
Deposit date:
2012-12-19

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