Efficacy of immune globulin in preventing complications of bone marrow transplantation: a meta-analysis.

Journal article

To assess the efficacy of immune globulin in preventing CMV infection, interstitial pneumonia, GVHD and death after BMT, we reviewed and synthesized data from 12 published studies (with 1282 patients) in which immune globulin was used prophylactically in BMT patients, controls were included and clinical outcomes were assessed. Data synthesis indicates that immune globulin significantly reduces fatal CMV infection (odds ratio (OR) 0.47, 95% confidence interval (CI) 0.23-0.99), CMV pneumonia (O...

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Authors: Bass, E; Powe, N; Goodman, SN; Graziano, S; Griffiths, R

• Journal: Bone marrow transplantation
• Volume: 12
• Issue: 3
• Pages: 273-282
• Publication date: 1993-09-01
• EISSN: 1476-5365
• ISSN: 0268-3369
• Language: English
• Keywords: Lung Diseases, Interstitial; Adult; Treatment Outcome; Cytomegalovirus Infections; Male; Bone Marrow Transplantation; Immunoglobulins; Evaluation Studies as Topic; Child; Epidemiologic Methods; Female; Immunoglobulins, Intravenous; Risk; Graft vs Host Disease; Odds Ratio; Humans