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Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus.

Abstract:

Recent studies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem has extensive connections with several motor centres in the CNS. This structure has also been implicated in the akinesia seen in patients with Parkinson's disease. Here we demonstrate that microinjection of gamma-aminobutyric acid (GABA) receptor A antagonist substance, bicuculline, into the PPN of non-human primates (n = 2) rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahyd...

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Publisher copy:
10.1093/brain/awf259
Journal:
Brain : a journal of neurology More from this journal
Volume:
125
Issue:
Pt 11
Pages:
2418-2430
Publication date:
2002-11-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950

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