Journal article
Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus.
- Abstract:
-
Recent studies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem has extensive connections with several motor centres in the CNS. This structure has also been implicated in the akinesia seen in patients with Parkinson's disease. Here we demonstrate that microinjection of gamma-aminobutyric acid (GABA) receptor A antagonist substance, bicuculline, into the PPN of non-human primates (n = 2) rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahyd...
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- Publisher copy:
- 10.1093/brain/awf259
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Authors
Bibliographic Details
- Journal:
- Brain : a journal of neurology
- Volume:
- 125
- Issue:
- Pt 11
- Pages:
- 2418-2430
- Publication date:
- 2002-11-01
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Source identifiers:
-
247681
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:247681
- UUID:
-
uuid:c894ff13-ecce-41d1-be1d-53cdb5651b18
- Local pid:
- pubs:247681
- Deposit date:
- 2013-02-20
Terms of use
- Copyright date:
- 2002
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