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A study of metabolic compartmentation in the rat heart and cardiac mitochondria using high-resolution magic angle spinning 1H NMR spectroscopy.

Abstract:

High-resolution magic angle spinning (MAS) (1)H nuclear magnetic resonance (NMR) spectroscopy is increasingly being used to monitor metabolic abnormalities within cells and intact tissues. Many toxicological insults and metabolic diseases affect subcellular organelles, particularly mitochondria. In this study high-resolution (1)H NMR spectroscopy was used to examine metabolic compartmentation between the cytosol and mitochondria in the rat heart to investigate whether biomarkers of mitochondr...

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Publication status:
Published

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Authors


Bollard, ME More by this author
Murray, AJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Nicholson, JK More by this author
Griffin, JL More by this author
Journal:
FEBS letters
Volume:
553
Issue:
1-2
Pages:
73-78
Publication date:
2003-10-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:c8920e59-5646-41bb-b02c-fad70f377153
Source identifiers:
106666
Local pid:
pubs:106666

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