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Stiffness post-total knee replacement: a proof of principle study investigating the effect of gene expression analysis of markers of fibrosis

Abstract:

Background: To establish proof of principle of a link between phenotypic expression and stiffness after TKR.
Methods: From 100 patients, genetic expression of markers of fibrosis was performed for 15 synovial samples from patients categorised as ‘best post-operative range of movement (ROM)’ and 15 samples from patients with ‘worst ROM’. These markers included Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases with Thrombospondin (... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.knee.2019.05.005

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Elsevier
Journal:
Knee More from this journal
Volume:
26
Issue:
4
Pages:
914-922
Publication date:
2019-06-05
Acceptance date:
2019-05-06
DOI:
ISSN:
1873-5800
Language:
English
Keywords:
Pubs id:
pubs:996536
UUID:
uuid:c88c9857-b799-42ef-9112-2c13f8f9e429
Local pid:
pubs:996536
Source identifiers:
996536
Deposit date:
2019-05-07

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