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Thesis

Mechanistic Studies on Histone Demethylases and Related Enzymes

Abstract:

Histone lysyl demethylases (2OG demethylases) are a family of nuclear proteins that catalyse the demethyation of Nε-methylated lysines on histone tails. 2OG demethylases belong to the 2-oxoglutarate and Fe(II) dependent dioxygenase superfamily, which utilise molecular oxygen to oxidise a wide variety of cellular substrates. The methylation states of histone lysines play crucial roles in regulating gene transcription, and consequently, the 2OG demethylases have been identified as important ...

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Institution:
University of Oxford
Research group:
C. J. Schofield
Oxford college:
Pembroke College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology
Role:
Author

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Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral

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