Mechanistic Studies on Histone Demethylases and Related Enzymes

Thesis

Abstract:: Histone lysyl demethylases (2OG demethylases) are a family of nuclear proteins that catalyse the demethyation of Nε-methylated lysines on histone tails. 2OG demethylases belong to the 2-oxoglutarate and Fe(II) dependent dioxygenase superfamily, which utilise molecular oxygen to oxidise a wide variety of cellular substrates. The methylation states of histone lysines play crucial roles in regulating gene transcription, and consequently, the 2OG demethylases have been identified as important ...
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Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Sub department:

Chemical Biology

Research group:

C. J. Schofield

Oxford college:

Pembroke College

Role:

Author

Role:

Supervisor

Language:: English
Keywords:: 2-oxoglutarate

demethylase

nuclear magnetic resonance

glutathione

histone

arginine

chromatin

oxygenase

enzyme kinetics

oxygen sensing

2OG

methylation

enzyme mechanism

formaldehyde

NMR

lysine

epigenetics
Subjects:: Protein chemistry

Chemical biology

NMR spectroscopy

Organic chemistry

Enzymes
UUID:: uuid:c88975b2-b960-422f-97b7-492296a901e6
Deposit date:: 2016-11-15

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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