- Abstract:
-
Histone lysyl demethylases (2OG demethylases) are a family of nuclear proteins that catalyse the demethyation of Nε-methylated lysines on histone tails. 2OG demethylases belong to the 2-oxoglutarate and Fe(II) dependent dioxygenase superfamily, which utilise molecular oxygen to oxidise a wide variety of cellular substrates. The methylation states of histone lysines play crucial roles in regulating gene transcription, and consequently, the 2OG demethylases have been identified as important ...
Expand abstract - Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Richard James Hopkinson
- Copyright date:
- 2011
- License:
- Restricted: Full content available from 2018-01-01 (ISO 8601)
Thesis
Mechanistic Studies on Histone Demethylases and Related Enzymes
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